51³Ô¹ÏÍø

ELE-101 is 51³Ô¹ÏÍø's patent-protected synthetic intravenous (IV) formulation of psilocin benzoate designed to offer the therapeutic benefits of psilocybin in a more consistent, controllable, and shorter treatment paradigm of approximately two hours. In the small proof-of-concept study (n=6) in patients with Major Depressive Disorder (MDD), a single 10 minute infusion of ELE-101 was shown to induce rapid, robust and lasting antidepressant effects, with a mean >20 point reduction in MADRS scores observed at all time points through to 3 months after dosing. ELE-101 was also shown to be well-tolerated and patients were deemed ready to be discharged by Investigators within a mean time of approximately 2 hours. Study follow-up is complete and further data will be available in 2025 and will be used to inform the future clinical development of ELE-101.

For World Mental Health Day, we spoke to Dr Rob Conley, our Chief Scientific and Medical Officer, to learn more about the current treatment landscape for mental health conditions like depression and substance use disorders and hear his hopes for the next generation of mental health treatments. As Chief Scientific and Medical Officer at 51³Ô¹ÏÍø, Rob oversees all of our clinical research and development. Rob previously served as Senior Vice President at Eleusis and Chief Science Officer, Late Phase Neuroscience at Eli Lilly and Co. Prior to that, he had a long clinical and academic career, first at the University of Pittsburgh, where he completed a Psychiatry residency and was Chief Resident, and then at the University of Maryland School of Medicine, where he remains an Adjunct Professor of Psychiatry and Psychopharmacology at Maryland.

51³Ô¹ÏÍø announced that it will be presenting data on BPL-003, a novel synthetic intranasal formulation of 5-MeO-DMT benzoate, in two poster presentations at the ECNP 2024 Congress in Milan, Italy on Sunday 22nd and Monday 23rd September. BPL-003 is 51³Ô¹ÏÍø’s novel synthetic intranasal formulation of 5-MeO-DMT benzoate and is currently under investigation in Phase II studies as a potential therapy for Treatment Resistant Depression and Alcohol Use Disorder. BPL-003 has been specifically designed to overcome some of the challenges of first-generation psychedelics and existing mental health treatments and produce rapid and lasting treatment effects within a short time in clinic of less than 2 hours.